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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
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Carbon Dioxide → L-chiro-Inositol, 4-amino-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl)-6-O-methyl-1-(methylamino)-

HRID 614456
ノート
印刷プレビュー

反応式

HRID 614456 の反応式
[CH3:1][N:2](C(CN)=O)[C@@H:3]1[C@@H:8]([O:9][CH3:10])[C@@H:7]([OH:11])[C@H:6]([NH2:12])[C@@H:5]([O:13][C@H:14]2[O:19][C@H:18]([CH2:20][NH2:21])[CH2:17][CH2:16][C@H:15]2[NH2:22])[C@@H:4]1[OH:23].[OH-].[Na+].[OH-].[Ba+2].[OH-].C(=O)=O>>[CH3:1][NH:2][C@@H:3]1[C@@H:8]([O:9][CH3:10])[C@@H:7]([OH:11])[C@H:6]([NH2:12])[C@@H:5]([O:13][C@H:14]2[O:19][C@H:18]([CH2:20][NH2:21])[CH2:17][CH2:16][C@H:15]2[NH2:22])[C@@H:4]1[OH:23]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 4

HCID 280Carbon DioxideHCID 14798Sodium HydroxideHCID 6093286Barium hydroxide2 回HCID 101316942HCID 101316942、化合物2 回

生成物 1

HCID 101281153L-chiro-Inositol, 4-amino-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl)-6-O-methyl-1-(methylamino)-

実験手順

Fortimicin KE may also be obtained by heating Fortimicin D in an alkaline aqueous solution such as sodium hydroxide and barium hydroxide. Specifically, Fortimicin D is heated in an aqueous solution of saturated barium hydroxide at a temperature of 100° C. for 3 hours. Then the reaction solution is neutralized with dry ice and the resulting precipitate of barium carbonate is removed by filtration. The filtrate is concentrated and passed through a column packed with Amberlite CG-50 (ammonium form). After washing the column with water, elution is carried out with 0.2N aqueous ammonia. First, a small amount of reaction by-products is eluted and subsequently Fortimicin KE is eluted. The fractions containing Fortimicin KE are combined and concentrated under reduced pressure. The concentrate is then freeze-dried to obtain the free base of Fortimicin KE.

後処理

  1. customthe resulting precipitate of barium carbonate is removed by filtration
  2. concentrationThe filtrate is concentrated
  3. washAfter washing the column
  4. washwith water, elution
  5. customFirst, a small amount of reaction by-products
  6. washis eluted
  7. washsubsequently Fortimicin KE is eluted
  8. additionThe fractions containing Fortimicin KE
  9. concentrationconcentrated under reduced pressure
  10. customThe concentrate is then freeze-dried

出典と根拠

ORDレコード
ord-6768d87d0532461fb90e6b08b1d13719
出典データセット
uspto-grants-1979_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04145253

反応ノート

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