Nitric Acid → HCID 12909298、化合物

HRID 614527ノート

反応式

HRID 614527 の反応式
[CH:1]1[N:9]2[C:4]([CH2:5][O:6][C:7]3[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=32)=[N:3][C:2]=1[C:14]([O:16][CH3:17])=[O:15].S(=O)(=O)(O)O.[N+:23]([O-])([OH:25])=[O:24]>O>[N+:23]([C:11]1[CH:12]=[CH:13][C:7]2[O:6][CH2:5][C:4]3=[N:3][C:2]([C:14]([O:16][CH3:17])=[O:15])=[CH:1][N:9]3[C:8]=2[CH:10]=1)([O-:25])=[O:24]

参加物

5

反応物 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 12909280HCID 12909280、化合物

生成物 1

HCID 12909298HCID 12909298、化合物収率 79%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

8.0 g of methyl 4H-imidazo-[2,1-c][1,4]-benzoxazine-2-carboxylate were added to a stirred mixture of 25 ml of concentrated sulfuric acid and 25 ml of concentrated nitric acid at 10° C. The ester slowly went into solution with the solution turning yellow and after three hours at room temperature, thin layer chromatography indicated no starting material remained. 500 ml of water were then added and the yellow product thus formed was filtered off, washed well with water and then dried over P2O5 to obtain 7.5 g (79% yield) of methyl 8-nitro-4H-imidazo-[2,1-c][1,4]-benzoxazine-2-carboxylate with a melting point of 270°-2° C.

後処理

  1. customthe yellow product thus formed
  2. filtrationwas filtered off
  3. washwashed well with water
  4. dry with materialdried over P2O5

出典と根拠

ORDレコード
ord-8ada9dd7c86d47a29bfcb9bf802d0b66
出典データセット
uspto-grants-1979_03
特許番号
US04145419

反応ノート

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