Benzyl Alcohol → Benzyl mesylate

HRID 614562

反応式

HRID 614562 の反応式
[CH2:1]([OH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:16][S:17](Cl)(=[O:19])=[O:18]>ClCCl>[CH3:16][S:17]([O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)(=[O:19])=[O:18]

参加物

5

反応物 3

HCID 244Benzyl AlcoholHCID 8471TriethylamineHCID 31297Methanesulfonyl chloride

生成物 1

HCID 148757Benzyl mesylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To an ice cooled solution of 54 g (0.5 mol) of benzyl alcohol and 75.75 g (104.3 ml, 0.75 mol) of triethylamine in 1800 ml of dichloromethane is added dropwise 63 g (42.57 ml, 0.55 mol) of methanesulfonyl chloride. The temperature of the reaction mixture during the addition is ca. 10°. The reaction mixture is then stirred for 1.5 hours at 10°. The reaction mixture is then diluted with dichloromethane, washed with ice water, cold 10% HCl, saturated KHCO3, saturated NaCl and dried (MgSO4). Solvent is removed in vacuo to yield the benzyl methanesulfonate as an oil.

後処理

  1. additionThe temperature of the reaction mixture during the addition
  2. customis ca. 10°
  3. washwashed with ice water, cold 10% HCl, saturated KHCO3, saturated NaCl
  4. dry with materialdried (MgSO4)
  5. customSolvent is removed in vacuo

出典と根拠

ORDレコード
ord-142440ae98ad4ede98e4142a5d04f31d
出典データセット
uspto-grants-1979_03
特許番号
US04145433

関連ノート

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