Hydrochloric Acid → 2-[2-(5-Methyl-4-imidazolylmethylthio)-ethylamino]-5-(2-phenylethyl)-4-pyrimidone dihydrochloride

HRID 614676

反応式

HRID 614676 の反応式
[C:1]1([CH2:7][CH2:8][C:9]2[C:10](=[O:16])[NH:11][C:12](=S)[NH:13][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(CCC2C(=O)NC(SC)=NC=2)C=CC=CC=1.N1C=CC=NC1=O.[CH3:41][C:42]1[NH:46][CH:45]=[N:44][C:43]=1[CH2:47][S:48][CH2:49][CH2:50][NH2:51].[ClH:52]>>[ClH:52].[ClH:52].[CH3:41][C:42]1[NH:46][CH:45]=[N:44][C:43]=1[CH2:47][S:48][CH2:49][CH2:50][NH:51][C:12]1[NH:11][C:10](=[O:16])[C:9]([CH2:8][CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:14][N:13]=1

参加物

6

反応物 5

HCID 313Hydrochloric AcidHCID 684012(1H)-PyrimidinoneHCID 6655684-(((2-Aminoethyl)thio)methyl)-5-methylimidazoleHCID 129459715-(2-Phenylethyl)-2-thiouracilHCID 129515085-Phenylethyl-2-methylthio-4-pyrimidone

生成物 1

HCID 233461712-[2-(5-Methyl-4-imidazolylmethylthio)-ethylamino]-5-(2-phenylethyl)-4-pyrimidone dihydrochloride

実験手順

5-(2-Phenylethyl)-2-thiouracil (1.8 g) was converted into 5-phenylethyl-2-methylthio-4-pyrimidone (m.p. 160°-161° ex ethanol) by the method described in Example 1(i). Reaction of this pyrimidone (1.55g) with 2-(5-methyl-4-imidazolylmethylthio)-ethylamine (1.1 g) by the method described in Example 1(ii) gave an oil which was dissolved in 2N hydrochloric acid, the solution evaporated to dryness and the residue recrystallised from methanol to give 2-[2-(5-methyl-4-imidazolylmethylthio)-ethylamino]-5-(2-phenylethyl)-4-pyrimidone dihydrochloride, m.p. 214°-218°.

後処理

  1. customgave an oil which
  2. customthe solution evaporated to dryness
  3. customthe residue recrystallised from methanol

出典と根拠

ORDレコード
ord-af83002c64c44d3c8e68996d9b692e00
出典データセット
uspto-grants-1979_03
特許番号
US04145546

関連ノート

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