Ethyl 3-oxo-2-(2-phenylethyl)butanoate → 5-(2-Phenylethyl)-6-methyl-2-thiouracil

HRID 614682

反応式

HRID 614682 の反応式
[C:1]1([CH2:7][CH2:8][CH:9]([C:15]([CH3:17])=O)[C:10](OCC)=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:18][C:19]([NH2:21])=[S:20].[O-]CC.[Na+].[Na]>C(O)C>[C:1]1([CH2:7][CH2:8][C:9]2[C:10](=[O:11])[NH:18][C:19](=[S:20])[NH:21][C:15]=2[CH3:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

6

反応物 4

HCID 219459Ethyl 3-oxo-2-(2-phenylethyl)butanoateHCID 2723790ThioureaHCID 2723922Sodium ethoxideHCID 5360545Sodium

生成物 1

HCID 129459705-(2-Phenylethyl)-6-methyl-2-thiouracil

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl α-(phenylethyl)acetoacetate (23.4g) and thiourea (10.65g) were added to a solution of sodium ethoxide in ethanol (100 ml) prepared from sodium (4.6g). The mixture was refluxed for 51/2 hours and evaporated to dryness. The solid residue was dissolved in water and acetic acid was added to pH 4. The white precipitate was filtered off and recrystallised from ethanol to give 5-(2-phenylethyl)-6-methyl-2-thiouracil m.p. 210°-214°.

後処理

  1. temperatureThe mixture was refluxed for 51/2 hours
  2. customevaporated to dryness
  3. dissolutionThe solid residue was dissolved in water
  4. additionacetic acid was added to pH 4
  5. filtrationThe white precipitate was filtered off
  6. customrecrystallised from ethanol

出典と根拠

ORDレコード
ord-65364b47c40c46e6a9ff5cf7862a9b86
出典データセット
uspto-grants-1979_03
特許番号
US04145546

関連ノート

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