Methyl iodide → 2-Amino-6-methylthio-9-(2-hydroxyethoxymethyl)purine

HRID 614942ノート

反応式

HRID 614942 の反応式
[OH:1][CH2:2][CH2:3][O:4][CH2:5][N:6]1[CH:14]=[N:13][C:12]2[C:11](=[S:15])[NH:10][C:9]([NH2:16])=[N:8][C:7]1=2.[CH3:17]I>CO>[NH2:16][C:9]1[N:8]=[C:7]2[C:12]([N:13]=[CH:14][N:6]2[CH2:5][O:4][CH2:3][CH2:2][OH:1])=[C:11]([S:15][CH3:17])[N:10]=1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 178508225HCID 178508225、化合物

生成物 1

HCID 205176832-Amino-6-methylthio-9-(2-hydroxyethoxymethyl)purine収率 38%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture 9-(2-Hydroxyethoxymethyl)thioguanine (0.7 g), methyl iodide (0.2 ml), Dewex HCO3- resin (1.7 g) and methanol (200 ml) was stirred overnight at room temperature. The resin was removed by filtration, washed with methanol and the combined filtration evaporated, and the residue recrystallized from isopropanol and then from acetone to give 2-amino-6-methylthio-9-(2-hydroxyethoxymethyl)purine, m.p. 188°-191° C. in 38% yield.

後処理

  1. customThe resin was removed by filtration
  2. washwashed with methanol
  3. filtrationthe combined filtration
  4. customevaporated
  5. customthe residue recrystallized from isopropanol

出典と根拠

ORDレコード
ord-f54537336d204a0bb4c55e1c9d542920
出典データセット
uspto-grants-1979_03
特許番号
US04146715

反応ノート

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