Dimethylformamide → HCID 13090790、化合物

反応式

[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[CH2:13]Cl.[Na].CN(C)[CH:18]=[O:19]>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[CH2:13][O:19][C:18]1[CH:9]=[CH:8][C:7]([Cl:12])=[CH:6][CH:5]=1

参加物

反応物 3

HCID 6228Dimethylformamide

HCID 5360545Sodium

HCID 13090784HCID 13090784、化合物

生成物 1

HCID 13090790HCID 13090790、化合物

実験手順

24.6 parts of 3,7-dichloro-8-chloromethylquinoline (Example 1) and 15 parts of sodium p-chlorophenate in 200 parts of dimethylformamide were stirred at 100° C. for 10 hours. The solvent was distilled off, water was added to the residue and the solid was filtered off with suction, dried and recrystallized from a suitable solvent. 32 parts of 3,7-dichloro-8-p-chlorophenoxymethylquinoline of melting point 110° C. were obtained. The yield corresponds to 95% of theory.