Hydroxyamine hydrochloride → 3,7-Dichloroquinoline-8-carbonitrile
反応式
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[CH2:13]Cl.Cl.[NH2:16]O.C([O-])=O.[Na+]>C(O)=O.O>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[C:13]#[N:16]参加物
6
実験手順
28.1 parts of 3,7-dichloro-8-chloromethylquinoline (Example 1), 6.95 parts of hydroxylamine hydrochloride and 13.6 parts of sodium formate in 200 ml of formic acid and 60 ml of water were stirred at 100° C. for 12 hours. The reaction solution was poured onto ice and the precipitated solid was filtered off with suction, washed neutral with water and dried. 19 parts of 3,7-dichloro-8-cyanoquinoline of melting point 222° C. were obtained. The yield corresponds to 78.5% of theory.
後処理
- additionThe reaction solution was poured onto ice
- filtrationthe precipitated solid was filtered off with suction
- washwashed neutral with water
- customdried
出典と根拠
- ORDレコード
- ord-e484d41706ac45d68675df1294a7149d
- 出典データセット
- uspto-grants-1985_02
- 特許番号
- US04497651
反応ノート
読み込み中…