N-(2-hydroxyethyl)-N'-(2-benzyloxybenzyl)urea → N-(2-hydroxyethyl)-N'-(2-hydroxybenzyl)urea
反応式
[OH:1][CH2:2][CH2:3][NH:4][C:5]([NH:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15]CC1C=CC=CC=1)=[O:6]>CO.[Pd]>[OH:1][CH2:2][CH2:3][NH:4][C:5]([NH:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[OH:15])=[O:6]参加物
4
実験手順
59.6 g of N-(2-hydroxyethyl)-N'-(2-benzyloxybenzyl)-urea are dissolved in 600 ml of methanol and hydrogenated in the presence of 6 g of Pd/C-catalyst (5%). After 2 hours the hydrogenation ceases. The catalyst is suction-filtered, and the filtrate concentrated by evaporation in vacuo. The residue is recrystallised from 350 ml of ethyl acetate; the pure product melts at 100°-101°.
後処理
- filtrationThe catalyst is suction-filtered
- concentrationthe filtrate concentrated by evaporation in vacuo
- customThe residue is recrystallised from 350 ml of ethyl acetate
出典と根拠
- ORDレコード
- ord-d1cfa1536c80498090b9440570f58620
- 出典データセット
- uspto-grants-1985_02
- 特許番号
- US04497813
反応ノート
読み込み中…