N-(2-Chloroethyl)dibenzylamine → 3-(2-Dibenzylaminoethoxy)salicylic acid methyl ester

HRID 615234

反応式

HRID 615234 の反応式
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[C:5]=1[OH:11].C(=O)([O-])[O-].[K+].[K+].[CH2:19]([N:26]([CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[CH2:27][CH2:28]Cl)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(#N)C>[CH3:1][O:2][C:3](=[O:12])[C:4]1[C:5](=[C:6]([O:10][CH2:28][CH2:27][N:26]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:7]=[CH:8][CH:9]=1)[OH:11]

参加物

5

反応物 3

HCID 5820N-(2-Chloroethyl)dibenzylamineHCID 11430Potassium CarbonateHCID 75484Methyl 2,3-Dihydroxybenzoate

生成物 1

HCID 539294463-(2-Dibenzylaminoethoxy)salicylic acid methyl ester

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2,3-dihydroxybenzoic acid methyl ester is reacted in the presence of potassium carbonate in acetonitrile with 1.1 equivalents of 1-dibenzylamino-2-chloroethane for 18 hours at 82°. The crude 3-(2-dibenzylaminoethoxy)-salicylic acid methyl ester obtained after working up is put to further use without further purification.

出典と根拠

ORDレコード
ord-bfd4af106aa846cdabaa6603de804460
出典データセット
uspto-grants-1985_02
特許番号
US04497813

関連ノート

読み込み中…