Hydroxyamine hydrochloride → 1-[5-Methyl-2-(4-pyridinyl)-1H-imidazol-4-yl]-ethanone oxime

HRID 615327ノート

反応式

HRID 615327 の反応式
[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[C:13](=O)[CH3:14].C([O-])(=O)C.[Na+].Cl.[NH2:22][OH:23]>O>[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[C:13](=[N:22][OH:23])[CH3:14]

参加物

5

反応物 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 133879391-[5-Methyl-2-(4-pyridinyl)-1H-imidazol-4-yl]ethanone

生成物 1

HCID 1363993111-[5-Methyl-2-(4-pyridinyl)-1H-imidazol-4-yl]-ethanone oxime

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a 1.0 g (0.005 mole) amount of 1-[5-methyl-2-(4-pyridinyl)-1H-imidazol-4-yl]ethanone (prepared as described in Example 24) dissolved in 200 ml of boiling water were added 1.0 g (0.012 mole) of sodium acetate and 0.7 g (0.01 mole) of hydroxylamine hydrochloride. The mixture was stirred and heated for 2 hours, then cooled to room temperature. The resulting precipitate was collected by filtration and when dried at 60° C. for 18 hours gave 0.7 g of the product of the Example as white crystals, mp 253°-255° C. (dec.).

後処理

  1. temperatureheated for 2 hours
  2. filtrationThe resulting precipitate was collected by filtration and when
  3. customdried at 60° C. for 18 hours

出典と根拠

ORDレコード
ord-1b477c8333b849b495209697c50baf6f
出典データセット
uspto-grants-1985_02
特許番号
US04499097

反応ノート

読み込み中…