Benzylamine → N-benzylpiperidin-4-amine
反応式
[C:1]([BH3-])#[N:2].[Na+].[CH2:5]([NH2:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[CH2:5]([NH:12][CH:6]1[CH2:5][CH2:1][NH:2][CH2:8][CH2:7]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1参加物
3
実験手順
The compounds of formula A and G are prepared as is described in Reaction Sequences 1 and 2. Compound G is then treated with sodium cyanoborohydride, optionally in the presence of benzylamine, to produce the 4-(benzyl)amino piperidine which is subsequently coupled with the compound of formula A to produce the benzyl derivative (formula G"). The compound of formula G" is then hydrogenated using, for instance, palladium-on-carbon catalyst to produce the compound of formula I.
後処理
- customThe compounds of formula A and G are prepared
- customas is described in Reaction Sequences 1 and 2
出典と根拠
- ORDレコード
- ord-746d12cd9afa47d7b19365652c6d5842
- 出典データセット
- uspto-grants-1985_02
- 特許番号
- US04499100
反応ノート
読み込み中…