4-Chlorophenyl Isocyanate → N-[(3-pyridyl)methyl]-N-(4-fluorophenyl)-(4-chlorophenylamino)carboxamide

HRID 615879ノート

反応式

HRID 615879 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]=[C:24]=[O:25])=[CH:19][CH:18]=1>C(OCC)(=O)C>[N:12]1[CH:13]=[CH:14][CH:15]=[C:10]([CH2:9][N:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[C:24]([NH:23][C:20]2[CH:21]=[CH:22][C:17]([Cl:16])=[CH:18][CH:19]=2)=[O:25])[CH:11]=1

参加物

4

反応物 2

HCID 76934-Chlorophenyl IsocyanateHCID 645683N-(4-Fluorophenyl)-3-pyridinemethanamine

生成物 1

HCID 13652447N-[(3-pyridyl)methyl]-N-(4-fluorophenyl)-(4-chlorophenylamino)carboxamide

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

N-[(3-pyridyl)methyl]-N-(4-fluorophenyl)-(4-chlorophenylamino)carboxamide was prepared by the method of Example 21 by reacting 5.0 g. of N-(4-fluorophenyl)-[(3-pyridyl)methyl]amine with 3.76 g. of 4-chlorophenylisocyanate in 200 ml. of ethyl acetate. Weight 1.8 g. M.P. 95°-96° C.

出典と根拠

ORDレコード
ord-ac0d2b06faaa4b23b914d80691590f40
出典データセット
uspto-grants-1985_02
特許番号
US04501746

反応ノート

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