Hydrogen Bromide → 4-(1-Methylpiperidin-3-yl)benzene-1,2-diol--hydrogen bromide (1/1)
反応式
Cl.[CH3:2][N:3]1[CH2:8][CH2:7][CH2:6][CH:5]([C:9]2[CH:14]=[CH:13][C:12]([O:15]C)=[C:11]([O:17]C)[CH:10]=2)[CH2:4]1.[BrH:19]>>[BrH:19].[CH3:2][N:3]1[CH2:8][CH2:7][CH2:6][CH:5]([C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([OH:17])[CH:10]=2)[CH2:4]1参加物
3
実験手順
A mixture of 8 g of the product of Step D in 40 ml of 66% hydrobromic acid was refluxed for an hour and then distilled to dryness under reduced pressure. The residue was dissolved in hot ethanol and the solution was cooled and vacuum filtered to obtain 2.49 g of N-methyl-3-(3',4'-dihydroxyphenyl)-piperidine hydrobromide as crystals melting at 190° C.
後処理
- temperaturewas refluxed for an hour
- distillationdistilled to dryness under reduced pressure
- dissolutionThe residue was dissolved in hot ethanol
- temperaturethe solution was cooled
- filtrationvacuum filtered
出典と根拠
- ORDレコード
- ord-e632f6c0e96542b191cc20acfbc3317c
- 出典データセット
- uspto-grants-1978_02
- 特許番号
- US04072685
反応ノート
読み込み中…