Sodium Dithionite → 2-amino-7,7-diethyl-6-(hydroxymethyl)-1,8-dihydropteridin-4-one

HRID 616249ノート

反応式

HRID 616249 の反応式
S(S([O-])=O)([O-])=O.[Na+].[Na+].[NH2:9][C:10]1[N:15]=[C:14]([OH:16])[C:13]([N+]([O-])=O)=[C:12]([NH:20][C:21]([CH2:29][CH3:30])([CH2:27][CH3:28])[C:22](=[N:25]O)[CH2:23][OH:24])[N:11]=1>[OH-].[Na+]>[NH2:9][C:10]1[N:15]=[C:14]([OH:16])[C:13]2[N:25]=[C:22]([CH2:23][OH:24])[C:21]([CH2:29][CH3:30])([CH2:27][CH3:28])[NH:20][C:12]=2[N:11]=1

参加物

4

反応物 2

HCID 24489Sodium DithioniteHCID 178446283HCID 178446283、化合物

生成物 1

HCID 1784367582-amino-7,7-diethyl-6-(hydroxymethyl)-1,8-dihydropteridin-4-one収率 3%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

Sodium dithionite was added portionwise to a warm solution of 2-amino-4-hydroxy-6-(1,1-diethyl-3-hydroxy-2-hydroxyiminopropylamino)-5-nitropyrimidine (II) (450 mg) in 0.1M sodium hydroxide until the colour changed from red to very pale yellow. A solid product was not obtained either on cooling or on adjusting the pH. In order to separate the product from inorganic material the solution was evaporated and the product extracted with ethanol and the inorganic material was filtered off. This extraction was repeated and the combined extracts were evaporated to dryness in vacuo. The residue was dissolved in the minimum quantity of water and placed on a column of Amberlite (C.G.50) ion exchange resin (2.5 × 28 cm). Elution with water gave two main fluorescent bands. Evaporation of the solution containing the first band gave the 6-carboxaldehyde derivative of the title compound (10 mg. yield 3%) as a bright orange powder, whilst the second band gave the 7,8-dihydropteridine (I) (160 mg. yield 44.5%%) as a bright yellow powder, m.p. >300° decomp.

後処理

  1. customA solid product was not obtained
  2. temperatureon cooling
  3. customIn order to separate the product from inorganic material the solution
  4. customwas evaporated
  5. extractionthe product extracted with ethanol
  6. filtrationthe inorganic material was filtered off
  7. extractionThis extraction
  8. customthe combined extracts were evaporated to dryness in vacuo
  9. dissolutionThe residue was dissolved in the minimum quantity of water
  10. washElution with water
  11. customgave two main fluorescent bands
  12. customEvaporation of the solution
  13. additioncontaining the first band

出典と根拠

ORDレコード
ord-a336c6dfb6e14afb94a760ef77d1e275
出典データセット
uspto-grants-1978_02
特許番号
US04073786

反応ノート

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