Formaldehyde → HCID 20369664、化合物

HRID 616316ノート

反応式

HRID 616316 の反応式
[C:1]1([N:7]2[C:11](=[O:12])[NH:10][C:9](=[O:13])[O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:14]=[O:15].O>CO.C(Cl)Cl>[C:1]1([N:7]2[C:11](=[O:12])[N:10]([CH2:14][OH:15])[C:9](=[O:13])[O:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

6

反応物 3

HCID 712FormaldehydeHCID 962WaterHCID 15620455N-PHENYL-3,5-OXADIAZOLIDIONE

生成物 1

HCID 20369664HCID 20369664、化合物

試薬・触媒・溶媒 2

HCID 887Methanol溶媒2 回HCID 6344Dichloromethane溶媒

実験手順

2-Phenyl-1,2,4-oxadiazolidin-3,5-dione (6.75 grams; 0.044 mole) dissolved in methanol (100 ml) and aqueous formaldehyde (5.67 ml of 37% conc.; 0.06 mole) were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture was heated at reflux, with stirring for a period of about 2 hours. After this time the reaction mixture was stripped of methanol and water to yield a solid residue. The residue was then dissolved in methylene chloride, and the resulting solution was washed with water. The washed solution was dried over anhydrous magnesium sulfate and stripped of solvent to yield the desired product 2-phenyl-4-hydroxymethyl-1,2,4-oxadiazolidin-3,5-dione as a solid residue.

後処理

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. temperatureThe reaction mixture was heated
  4. temperatureat reflux
  5. customto yield a solid residue
  6. washthe resulting solution was washed with water
  7. dry with materialThe washed solution was dried over anhydrous magnesium sulfate

出典と根拠

ORDレコード
ord-aac74f6b5a014ee1bd9087154ca51db9
出典データセット
uspto-grants-1978_02
特許番号
US04073894

反応ノート

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