Triethylamine → HCID 178472718、化合物

HRID 616359ノート

反応式

HRID 616359 の反応式
[CH2:1]([O:3][C:4](=[O:12])[CH2:5][NH:6][CH2:7][CH:8]([O:10][CH3:11])[CH3:9])[CH3:2].C(N(CC)CC)C.[N:20]#[N:21].[CH3:22][O:23][C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][C:33]=1[O:34][CH3:35])[CH:30]=[C:29]([S:36]([NH:39][C@H:40]([C:48](Cl)=[O:49])[CH2:41][CH2:42][CH2:43][NH:44][C:45](=[NH:47])[NH2:46])(=[O:38])=[O:37])[CH:28]=[CH:27]2>C(Cl)(Cl)Cl>[N:20]#[N:21].[CH2:1]([O:3][C:4](=[O:12])[CH2:5][N:6]([C:48](=[O:49])[C@H:40]([CH2:41][CH2:42][CH2:43][NH:44][C:45](=[NH:46])[NH2:47])[NH:39][S:36]([C:29]1[CH:28]=[CH:27][C:26]2[C:31](=[CH:32][C:33]([O:34][CH3:35])=[C:24]([O:23][CH3:22])[CH:25]=2)[CH:30]=1)(=[O:38])=[O:37])[CH2:7][CH:8]([O:10][CH3:11])[CH3:9])[CH3:2]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 20369646N-(2-methoxypropyl)glycine ethyl esterHCID 178486633HCID 178486633、化合物

生成物 1

HCID 178472718HCID 178472718、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

To a stirred solution of 1.3 g of N-(2-methoxypropyl)glycine ethyl ester and 1.7 ml of triethylamine in 50 ml of chloroform, which was cooled in an ice-salt bath, was added in portions N2 -(6, 7-dimethoxy-2-naphthylsulfonyl)-L-arginyl chloride which was obtained in Example 3. The reaction mixture was stirred overnight at room temperature. At the end of this period, 50 ml of chloroform was added and the chloroform solution was washed twice with 50 ml of saturated sodium chloride solution, dried over anhydrous sodium sulfate and evaporated in vacuo. The oily residue was washed with ether to give 2.4 g of powdery N2 -(6, 7-dimethoxy-2-naphthylsulfonyl)-L-arginyl-N-(2-methoxypropyl)glycine ethyl ester.

後処理

  1. customwas obtained in Example 3
  2. washthe chloroform solution was washed twice with 50 ml of saturated sodium chloride solution
  3. dry with materialdried over anhydrous sodium sulfate
  4. customevaporated in vacuo
  5. washThe oily residue was washed with ether

出典と根拠

ORDレコード
ord-5e4b51a86e2340dda22be4e0365cbc5b
出典データセット
uspto-grants-1978_02
特許番号
US04073892

反応ノート

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