Benzoyl chloride, 3-nitro- → 4,5-Dimethoxy-2-(3-nitrophenyl)aminobenzamide

HRID 61637

反応式

HRID 61637 の反応式
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH3:14])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[N+:15]([C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)C(Cl)=O)([O-:17])=[O:16]>N1C=CC=CC=1>[CH3:12][O:11][C:9]1[C:8]([O:13][CH3:14])=[CH:7][C:3]([C:4]([NH2:6])=[O:5])=[C:2]([NH:1][C:25]2[CH:24]=[CH:20][CH:19]=[C:18]([N+:15]([O-:17])=[O:16])[CH:26]=2)[CH:10]=1

参加物

4

反応物 2

HCID 8495Benzoyl chloride, 3-nitro-HCID 108672362-Amino-4,5-dimethoxybenzamide

生成物 1

HCID 668250984,5-Dimethoxy-2-(3-nitrophenyl)aminobenzamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a suspension of 2-amino-4,5-dimethoxybenzamide (5.05 g, 25.7 mmole) and 3-nitro benzoyl chloride (5.2 g, 28.0 mmole) CHCl3 (120 ml) was added pyridine (50 ml) drop wise at RT. The reaction mixture was stirred at RT for 24 h. The solvent was removed in vacuo and residue was triturated with Et2O, filtered and dried under high vacuum to give 4,5-dimethoxy-2-(3-nitrophenyl)aminobenzamide, which was used directly in the next step.

後処理

  1. customThe solvent was removed in vacuo and residue
  2. customwas triturated with Et2O
  3. filtrationfiltered
  4. customdried under high vacuum

出典と根拠

ORDレコード
ord-41cca07868b74e43a295ba5f4044bd66
出典データセット
uspto-grants-2016_09
特許番号
US09440961B2

関連ノート

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