HCID 20388954、化合物 → 3-(2-Methyl-1,3-thiazol-5-yl)propan-1-ol
反応式
[CH3:1][C:2]1[S:3][C:4]([CH2:7][CH2:8][C:9](OC)=[O:10])=[CH:5][N:6]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH3:1][C:2]1[S:3][C:4]([CH2:7][CH2:8][CH2:9][OH:10])=[CH:5][N:6]=1参加物
4
実験手順
10.9 g of methyl 2-methyl-5-thiazole-propanoate in 70 ml of tetrahydrofuran was slowly added with stirring at 10°-15° C to a mixture of 125 ml of tetrahydrofuran and 3.42 g of lithium aluminum hydride at 10° C and the mixture was stirred for about 30 minutes. Then, tetrahydrofuran containing 20% water was slowly added and the mixture was filtered. The filter was washed with ethyl acetate and the filtrate was dried over magnesium sulfate and concentrated under reduced pressure to obtain 8.4 g of raw product which was rectified under reduced pressure to obtain 6.4g of 2-methyl-5-thiazole propanol with a boiling point of 106° C under 0.05 mm Hg.
後処理
- filtrationthe mixture was filtered
- washThe filter was washed with ethyl acetate
- dry with materialthe filtrate was dried over magnesium sulfate
- concentrationconcentrated under reduced pressure
- customto obtain 8.4 g of raw product which
出典と根拠
- ORDレコード
- ord-f329d76be58645709fdad2cefed6c71b
- 出典データセット
- uspto-grants-1978_02
- 特許番号
- US04073919
反応ノート
読み込み中…