反応式
[Br:1][C:2]1[CH:9]=[C:8]([Br:10])[CH:7]=[C:4]([CH:5]=O)[C:3]=1[OH:11].[C:12]([NH2:16])([CH3:15])([CH3:14])[CH3:13].N.[ClH:18]>C(O)C.CCOCC.C(O)=O>[ClH:18].[C:12]([NH:16][CH2:5][C:4]1[CH:7]=[C:8]([Br:10])[CH:9]=[C:2]([Br:1])[C:3]=1[OH:11])([CH3:15])([CH3:14])[CH3:13]参加物
8
実験手順
7 gm of 3,5-dibromo-salicylaldehyde, 17.5 gm of tert. butylamine and 7.7 gm of formic acid were heated for 6 hours at 70°-80° C. Subsequently, the reaction mixture was admixed with aqueous 2 N ammonia, vigorously shaken, and the precipitate formed thereby was sucked off. The residue was dissolved in ethanol, acidified with ethanolic hydrochloric acid and admixed with ether in order to crystallize the product out. N-tert.butyl-3,5-dibromo-2-hydroxy-benzylamine hydrochloride, m.p. 216°-220° C (decomp.), was obtained after recrystallization from absolute ethanol/ether.
後処理
- customthe precipitate formed
- customto crystallize the product out
出典と根拠
- ORDレコード
- ord-3136111fc16f4cebb7a7f3363b4d7f1b
- 出典データセット
- uspto-grants-1978_02
- 特許番号
- US04073942
関連ノート
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