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2-(2-Chlorophenoxymethyl)oxirane → 1-[3-(o-Chloro-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(2-Chlorophenoxymethyl)oxirane | HCID 137500 | — |
| 反応物 | 1-(Piperidin-4-yl)-1,3-diazinan-2-one | HCID 15572666 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-[3-(o-Chloro-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine | HCID 20368054 | — |
反応手順
A solution of 9.2 g of 1-(o-chloro-phenoxy)-2,3-epoxy-propane and 9.15 g of 1-(4-piperidyl)-2-oxo-hexahydro-pyrimidine in 7 ml of abs. ethanol is heated for 5 hours to 95° C and then evaporated in vacuo. The residue is recrystallised from chloroform/petroleum ether to yield the 1-[3-(o-chloro-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine, which melts at 150°-153° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04075335 |
| 出典データセット | uspto-grants-1978_02 |
| ORD ID | ord-6351b52759b7494a976e3ade071d5620 |
| 出典メモ | uspto-grants-1978_02 |