Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-2-(3-methoxyphenyl)- → Pyrazolo(5,1-a)isoquinoline, 2-(m-methoxyphenyl)-

HRID 616721ノート

反応式

HRID 616721 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:21]=[C:12]3[C:13]4[C:18]([CH2:19][CH2:20][N:11]3[N:10]=2)=[CH:17][CH:16]=[CH:15][CH:14]=4)[CH:6]=[CH:7][CH:8]=1>O=[Mn]=O.C1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:21]=[C:12]3[C:13]4[C:18]([CH:19]=[CH:20][N:11]3[N:10]=2)=[CH:17][CH:16]=[CH:15][CH:14]=4)[CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 1

HCID 3045616Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-2-(3-methoxyphenyl)-

生成物 1

HCID 3045617Pyrazolo(5,1-a)isoquinoline, 2-(m-methoxyphenyl)-

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 241Benzene溶媒

実験手順

To a solution of 2.5 g. of 2-(m-methoxyphenyl)-5,6-dihydro-pyrazolo[5,1-a]isoquinoline in 100 ml. of benzene is gradually added with stirring 30 g. of MnO2 prepared as described by E. Pratt et al., J. Org. Chem. 26, 2973 (1961) and activated according to the procedure of J. M. Goldman, J. Org. Chem. 34, 1979 (1969). The obtained mixture is refluxed with stirring for five days, then filtered. The filtrate after evaporation and crystallization of the solid residue from isopropyl ether gives 1 g. of the title product, m.p. 109°-11° C.

後処理

  1. temperatureThe obtained mixture is refluxed
  2. stirringwith stirring for five days
  3. filtrationfiltered
  4. customThe filtrate after evaporation and crystallization of the solid residue from isopropyl ether
  5. customgives 1 g

出典と根拠

ORDレコード
ord-d765ab1f51f54d80a2975aae4695cbcd
出典データセット
uspto-grants-1978_02
特許番号
US04075342

反応ノート

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