Water → N-(7-Oxo-4,5,6,7-tetrahydro-1-benzothiophen-4-yl)formamide

HRID 616773ノート

反応式

HRID 616773 の反応式
S1CCS[C:2]21[C:10]1[S:11][CH:12]=[CH:13][C:9]=1[CH:8]([NH:14][CH:15]=[O:16])[CH2:7][CH2:6]2.O.C(=O)([O-])[O-:19].[Ca+2]>C(#N)C>[O:19]=[C:2]1[C:10]2[S:11][CH:12]=[CH:13][C:9]=2[CH:8]([NH:14][CH:15]=[O:16])[CH2:7][CH2:6]1

参加物

5

反応物 3

HCID 962WaterHCID 10112Calcium CarbonateHCID 86735494N-(5,6-dihydrospiro[benzo-[b]thiophen-7(4H), 2'-[1,3]dithiolan]-4-yl)formamide

生成物 1

HCID 23347790N-(7-Oxo-4,5,6,7-tetrahydro-1-benzothiophen-4-yl)formamide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

実験手順

To a stirred mixture of N-(5,6-dihydrospiro[benzo[b]thiophen-7(4H), 2'-[1,3]dithiolan]-4-yl)formamide (1.5 g), acetonitrile (20 ml) and water is added calcium carbonate (1.65 g) and mercuric chloride (3.0 g). The mixture is stirred at room temperature for 35 minutes and acetonitrile is added. The solid is filtered and washed with acetonitrile. The filtrate (100 ml) is evaporated to dryness to afford the title compound.

後処理

  1. filtrationThe solid is filtered
  2. washwashed with acetonitrile
  3. customThe filtrate (100 ml) is evaporated to dryness

出典と根拠

ORDレコード
ord-7f73a915c0554e53939d5a1c7abb6cb1
出典データセット
uspto-grants-1978_02
特許番号
US04075228

反応ノート

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