反応式
[F:1][C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[NH:6][C:5]2[CH:13]=[CH:14][CH:15]=[CH:16][C:4]=2[CH:3]=1.[C:17](Cl)([Cl:19])=[O:18]>C1(C)C=CC=CC=1>[F:1][C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([C:17]([Cl:19])=[O:18])[C:5]2[CH:13]=[CH:14][CH:15]=[CH:16][C:4]=2[CH:3]=1参加物
4
反応条件
- 温度
- 25 °C
実験手順
A mixture of 2.3 g of 10-fluoro-5H-dibenz[b,f]azepine and 30 ml of toluene saturated with phosgene is stirred for 2 days at 25° C. Excess phosgene is then expelled with nitrogen and the reaction mixture is concentrated by rotary evaporation to yield crude 10-fluoro-5H-dibenz[b,f]azepine-5-carbonyl chloride as residue.
後処理
- concentrationthe reaction mixture is concentrated by rotary evaporation
出典と根拠
- ORDレコード
- ord-84342a3214e94d54b38ef2410a598ec3
- 出典データセット
- uspto-grants-1978_02
- 特許番号
- US04076812
関連ノート
読み込み中…