Hydrochloric Acid → 2-Amino-4-methoxybenzoic acid

HRID 617121

反応式

HRID 617121 の反応式
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:3]=1[C:4](N)=[O:5].Cl.[OH-:14].[Na+]>>[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:14])=[O:5]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 140230022-Amino-4-methoxybenzamide

生成物 1

HCID 3510102-Amino-4-methoxybenzoic acid

実験手順

A solution of 27.4 g (0.165 mol) of 2-amino-4-methoxybenzamide in 500 mL of 1N sodium hydroxide was stirred and heated under reflux for 18 hours. After the reaction mixture had cooled to room temperature the solution was brought to pH 6-7 with 0.5N HCl. A white precipitate formed which was collected by vacuum filtration. The crystals were rinsed with water and dried overnight at 100° C. The product amounted to 23.9 g. An analytical sample (mp 176-178° C.) was obtained by recrystallization from ethyl acetate.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 18 hours
  3. customA white precipitate formed which
  4. filtrationwas collected by vacuum filtration
  5. washThe crystals were rinsed with water
  6. customdried overnight at 100° C
  7. customAn analytical sample (mp 176-178° C.) was obtained by recrystallization from ethyl acetate

出典と根拠

ORDレコード
ord-675984d37fee4c66b5d8a3c04ab04ac6
出典データセット
uspto-grants-1999_09
特許番号
US05948775

関連ノート

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