Thionyl Chloride → 5-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester
反応式
[N:1]1[CH:6]=[C:5]([C:7]([O-])=[O:8])[CH:4]=[CH:3][C:2]=1[C:10]([O:12][CH3:13])=[O:11].S(Cl)([Cl:16])=O>>[C:10]([C:2]1[CH:3]=[CH:4][C:5]([C:7]([Cl:16])=[O:8])=[CH:6][N:1]=1)([O:12][CH3:13])=[O:11]参加物
3
実験手順
In step a, the carboxylic acid functionality of the appropriate 2,5-pyridinedicarboxylic acid, 2-methyl ester 10 (Nippon Kagaku Zasshi, 1967, 88, 563) is converted to its acid chloride using techniques and procedures well known and appreciated by one of ordinary skill in the art, such as thionyl chloride, to give the corresponding 6-carbomethoxynicotinoyl chloride 11.
出典と根拠
- ORDレコード
- ord-12710f0f2f89454fb66fb185cd6524b5
- 出典データセット
- uspto-grants-1999_09
- 特許番号
- US05948886
反応ノート
読み込み中…