1-Hydroxybenzotriazole → HCID 15435307、化合物

HRID 617652ノート

反応式

HRID 617652 の反応式
[CH2:1]([O:8][C:9]([NH:11][C:12]1[C:13](=[O:29])[N:14]([CH2:25][C:26](O)=[O:27])[CH:15]=[C:16]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:17]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:30][CH:31]([CH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)[CH:32]([OH:37])[C:33]([F:36])([F:35])[F:34].CCN=C=NCCCN(C)C.Cl.C1C=CC2N(O)N=NC=2C=1>CN(C=O)C>[CH2:1]([O:8][C:9]([NH:11][C:12]1[C:13](=[O:29])[N:14]([CH2:25][C:26]([NH:30][CH:31]([CH2:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[CH:32]([OH:37])[C:33]([F:34])([F:35])[F:36])=[O:27])[CH:15]=[C:16]([CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:17]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:1]([O:8][C:9]([NH:11][C:12]1[C:13](=[O:29])[N:14]([CH2:25][C:26]([NH:30][CH:31]([CH2:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[C:32](=[O:37])[C:33]([F:35])([F:36])[F:34])=[O:27])[CH:15]=[C:16]([CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:17]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

7

反応物 4

HCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 11741222HCID 11741222、化合物HCID 145032493-Amino-1,1,1-trifluoro-4-phenylbutan-2-ol

生成物 2

HCID 15435307HCID 15435307、化合物HCID 21851370HCID 21851370、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2-(3-Benzyloxycarbonylamino-5-benzyl-2-oxo-1,2-dihydro-1-pyridyl)-N-(1-benzyl-3,3,3-trifluoro-2-hydroxypropyl)acetamide was synthesized in the same manner as in Example 1. That is, 2-(3-benzyloxycarbonylamino-5-benzyl-2-oxo-1,2-dihydro-1-pyridyl)acetic acid (title compound in Reference Example 7, 380 mg, 0.968 mmol) was treated with 3-amino-1,1,1-trifluoro-4-phenyl-2-butanol (title compound in Reference Example 1, 249 mg, 1.14 mmol), WSCI hydrochloride (277 mg, 1.45 mmol) and HOBT (158 mg, 1.17 mmol) in DMF (10 mL) to give 428 mg (74%) of the target compound as a slightly yellow solid.

出典と根拠

ORDレコード
ord-f8e5d6318fea4dddb228265e350d27c7
出典データセット
uspto-grants-1999_09
特許番号
US05948785

反応ノート

読み込み中…