Nitrogen → 5-Phthalimido-1-pentanol

HRID 617714

反応式

HRID 617714 の反応式
[C:1]1(=[O:11])[O:6][C:4](=O)[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[NH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][OH:18].N#N>O>[C:4]1(=[O:6])[N:12]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][OH:18])[C:1](=[O:11])[C:2]2=[CH:10][CH:9]=[CH:8][CH:7]=[C:3]12

参加物

5

反応物 3

HCID 947NitrogenHCID 6811Phthalic AnhydrideHCID 756345-Aminopentan-1-ol

生成物 1

HCID 5948445-Phthalimido-1-pentanol収率 100%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
145 °C

実験手順

A mixture of phthalic anhydride (6.46 g, 43.6 mmol) and 5-aminopentanol (4.5 g, 43.6 mmol) was heated to 145° C. in an open flask for 30 min. A stream of N2 was applied to expel water vapor. After cooled to room temperature, the reaction residue was dried on vacuum pump. The product was obtained as colorless oil: yield 100%; 1H NMR (CDCl3) δ 1.4-1.5 (m, 2H), 1.6-1.8 (m, 4H), 3.6 (t, 2H, J=6.5), 3.7 (t, J=7.2 Hz), 7.7 (m, 2H), 7.8-7.9 (m, 2H).

後処理

  1. temperatureAfter cooled to room temperature
  2. customthe reaction residue was dried on vacuum pump
  3. customThe product was obtained as colorless oil

出典と根拠

ORDレコード
ord-a9c75197f9f34859b066480ac23af5ee
出典データセット
uspto-grants-1999_09
特許番号
US05952307

関連ノート

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