1-Benzyloxycarbonylamino3-([1,8]naphthyridin-2-yl)-propane → 3-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)propan-1-amine

HRID 617902

反応式

HRID 617902 の反応式
C(OC([NH:11][CH2:12][CH2:13][CH2:14][C:15]1[CH:24]=[CH:23][C:22]2[C:17](=[N:18][CH:19]=[CH:20][CH:21]=2)[N:16]=1)=O)C1C=CC=CC=1.[H][H]>CCO.[Pd].[C]>[N:16]1[C:17]2[NH:18][CH2:19][CH2:20][CH2:21][C:22]=2[CH:23]=[CH:24][C:15]=1[CH2:14][CH2:13][CH2:12][NH2:11]

参加物

5

反応物 2

HCID 218500091-Benzyloxycarbonylamino3-([1,8]naphthyridin-2-yl)-propaneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 98775993-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)propan-1-amine

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

A mixture of 1-7 (0.40 g, 1.24 mmol) and 10% Pd/carbon (0.08 g) in EtOH (12 mL) was stirred under a balloon of hydrogen for 20 h. Filtration through a celite pad and then evaporative removal of the filtrate solvent gave 1-8 as a colorless oil.

後処理

  1. filtrationFiltration through a celite pad
  2. customremoval of the filtrate solvent

出典と根拠

ORDレコード
ord-b76cde09736546e88cde543518f2299b
出典データセット
uspto-grants-1999_09
特許番号
US05952341

関連ノート

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