関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 3',4',5'-Trimethoxyacetophenone | HCID 14345 | — |
| 反応物 | 5-nitro-1H-indole-3-carbaldehyde | HCID 246039 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (E)-3-(5-Nitroindol-3-yl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one | HCID 21850180 | 5.3% |
反応手順
3',4',5'-Trimethoxyacetophenone (1.31 g) and 5-nitroindole-3-carboxaldehyde (1.18 g) were dissolved in N,N-dimethylformamide (20 ml), and piperidine (528.7 mg) was added thereto, followed by stirring at 100° C. for 72 hours. The reaction solution was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography. The obtained crude crystals were recrystallized from methanol to give Compound 21 (125 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05952355 |
|---|
| 出典データセット | uspto-grants-1999_09 |
|---|
| ORD ID | ord-e5fc7ad1fae14f72a4885117db483730 |
|---|
| 出典メモ | uspto-grants-1999_09 |
|---|
