反应详情

温度

100 °C

3',4',5'-Trimethoxyacetophenone (1.31 g) and 5-nitroindole-3-carboxaldehyde (1.18 g) were dissolved in N,N-dimethylformamide (20 ml), and piperidine (528.7 mg) was added thereto, followed by stirring at 100° C. for 72 hours. The reaction solution was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography. The obtained crude crystals were recrystallized from methanol to give Compound 21 (125 mg).

1. concentrationThe reaction solution was concentrated under reduced pressure
2. customthe residue was purified by silica gel column chromatography
3. customThe obtained crude crystals
4. customwere recrystallized from methanol