3',4',5'-Trimethoxyacetophenone → (E)-3-(6-Methoxyindol-3-yl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one

HRID 618114

反応式

HRID 618114 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13](=[O:15])[CH3:14])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[CH3:16][O:17][C:18]1[CH:26]=[C:25]2[C:21]([C:22]([CH:27]=O)=[CH:23][NH:24]2)=[CH:20][CH:19]=1>>[CH3:16][O:17][C:18]1[CH:26]=[C:25]2[C:21]([C:22](/[CH:27]=[CH:14]/[C:13]([C:5]3[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=3)=[O:15])=[CH:23][NH:24]2)=[CH:20][CH:19]=1

参加物

3

反応物 2

HCID 143453',4',5'-TrimethoxyacetophenoneHCID 9072146-Methoxy-1H-indole-3-carboxaldehyde

生成物 1

HCID 21850283(E)-3-(6-Methoxyindol-3-yl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one収率 32%

実験手順

Substantially the same procedure as in Example 1 was repeated using 3',4',5'-trimethoxyacetophenone (659 mg) and 6-methoxyindole-3-carboxaldehyde (550 mg) except that the reaction solution was concentrated under reduced pressure, that the residue was purified by silica gel column chromatography, and that the obtained crude crystals were recrystallized from ethanol, to give Compound 39 (369 mg).

後処理

  1. concentrationwas concentrated under reduced pressure, that the residue
  2. customwas purified by silica gel column chromatography
  3. customthat the obtained crude crystals
  4. customwere recrystallized from ethanol

出典と根拠

ORDレコード
ord-f3c262c37ecd43e0955d3e99bad2ecf7
出典データセット
uspto-grants-1999_09
特許番号
US05952355

関連ノート

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