Dimethylformamide → 6-Ethyl-1H-indole-3-carbaldehyde

HRID 618130

反応式

HRID 618130 の反応式
P(Cl)(Cl)(Cl)=O.[CH2:6]([C:8]1[CH:16]=[C:15]2[C:11]([CH:12]=[CH:13][NH:14]2)=[CH:10][CH:9]=1)[CH3:7].[OH-].[Na+].CN(C)[CH:21]=[O:22]>>[CH2:6]([C:8]1[CH:16]=[C:15]2[C:11]([C:12]([CH:21]=[O:22])=[CH:13][NH:14]2)=[CH:10][CH:9]=1)[CH3:7]

参加物

5

反応物 4

HCID 6228Dimethylformamide2 回HCID 14798Sodium HydroxideHCID 24813Phosphorus oxychlorideHCID 183302676-ethyl-1H-indole

生成物 1

HCID 218501566-Ethyl-1H-indole-3-carbaldehyde

実験手順

Phosphorus oxychloride (3.82 g) was added to N,N-dimethylformamide (20 ml), and the mixture was stirred at room temperature for 10 minutes. A solution of 6-ethylindole [Journal of the Chemical Society (J. Chem. Soc.), 7165 (1965)] in N,N-dimethylformamide (6 ml) was added to the reaction solution, and the mixture was stirred at room temperature for one hour. Ice (20 g) and then a 5N aqueous solution of sodium hydroxide (34 ml) were added to the reaction solution, and the mixture was heated under reflux for one hour. The reaction solution was ice-cooled, and the precipitated crystals were collected by filtration to give 6-ethylindole-3-carboxaldehyde (2.76 g).

後処理

  1. stirringthe mixture was stirred at room temperature for one hour
  2. temperaturethe mixture was heated
  3. temperatureunder reflux for one hour
  4. temperaturecooled
  5. filtrationthe precipitated crystals were collected by filtration

出典と根拠

ORDレコード
ord-20a4dc9d96584dd39f0523e402c8b79a
出典データセット
uspto-grants-1999_09
特許番号
US05952355

関連ノート

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