化工社化工社 化学情報印刷レポート · 研究参考用
Piperidine → 1-(2,5-Dimethoxyphenyl)-3-(indol-3-yl)-2-propen-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | Indole-3-Carboxaldehyde | HCID 10256 | — |
| 反応物 | 2',5'-Dimethoxyacetophenone | HCID 70991 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-(2,5-Dimethoxyphenyl)-3-(indol-3-yl)-2-propen-1-one | HCID 54156913 | 44% |
反応手順
2',5'-Dimethoxyacetophenone (1.80 g) and indole-3-carboxaldehyde (1.45 g) were dissolved in ethanol (20 ml), and piperidine (0.85 g) was added thereto, followed by heating under reflux for 72 hours. The precipitated crystals were collected by filtration, and the obtained crude crystals were recrystallized from ethanol to give Compound 89 (1.35 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05952355 |
| 出典データセット | uspto-grants-1999_09 |
| ORD ID | ord-05fe39220067459285c6760684758e9b |
| 出典メモ | uspto-grants-1999_09 |