Water → (2,6-Dimethyl-3-nitrophenyl)methanol

HRID 618239

反応式

HRID 618239 の反応式
[CH3:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([CH3:14])[C:3]=1[C:4](O)=[O:5].B.O>O1CCCC1>[CH3:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([CH3:14])[C:3]=1[CH2:4][OH:5]

参加物

5

反応物 3

HCID 962WaterHCID 6331BoraneHCID 2393292,6-Dimethyl-3-nitrobenzoic acid

生成物 1

HCID 10487641(2,6-Dimethyl-3-nitrophenyl)methanol収率 93.8%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
75 °C

実験手順

2,6-Dimethyl-3-nitrobenzoic acid (10 g) was dissolved in 100 ml of dry tetrahydrofuran and 165 ml of 1M borane in tetrahydrofuran added. The mixture was heated to 75° C. for 4 hr. The mixture was cooled to room temperature and the excess reagent slowly decomposed with water and the solvent evaporated. The residue was treated with ethyl acetate, washed with 1M hydrochloric acid, then with water, dried, and evaporated to give 8.71 g of (2,6-dimethyl-3-nitro-phenyl)-methanol, mp 94.5-96.1° C. ##STR124##

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. customthe solvent evaporated
  3. additionThe residue was treated with ethyl acetate
  4. washwashed with 1M hydrochloric acid
  5. dry with materialwith water, dried
  6. customevaporated

出典と根拠

ORDレコード
ord-57dc12dc7ae8494196565dd1f0c22521
出典データセット
uspto-grants-1999_09
特許番号
US05952362

関連ノート

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