HCID 18391989、化合物 → (R)-(3-Pyrrolidineoxy)tetrahydro-2H-pyran

HRID 618281ノート

反応式

HRID 618281 の反応式
C([N:8]1[CH2:12][CH2:11][C@@H:10]([O:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][O:15]2)[CH2:9]1)C1C=CC=CC=1>[OH-].[OH-].[Pd+2].CO>[O:15]1[CH2:16][CH2:17][CH2:18][CH2:19][CH:14]1[O:13][C@@H:10]1[CH2:11][CH2:12][NH:8][CH2:9]1

参加物

4

反応物 1

HCID 18391989HCID 18391989、化合物

生成物 1

HCID 18392016(R)-(3-Pyrrolidineoxy)tetrahydro-2H-pyran収率 122.8%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

A mixture of 1-benzyl-3-(R)-tetrahydropyranyloxypyrolidine(8.78 g, 27.3 mmol) and Pearlman's catalyst (3.50 g) in MeOH (100 ml) was stirred under hydrogen atmosphere at rt for 4 h. After removal of the catalyst by Celite filtration, the filtrate was concentrated to give 5.74 g of clear light brown oil. This was used for the next reaction without purification.

後処理

  1. customAfter removal of the catalyst
  2. filtrationby Celite filtration
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-b67e295ffa9640e4ae17ec6300c093c3
出典データセット
uspto-grants-1999_09
特許番号
US05952369

反応ノート

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