化工社化工社 化学情報印刷レポート · 研究参考用
L-Glutamic Acid → [[(2,4-Diamino-6-Pteridinyl)Methyl]Methyl Amino] Benzoic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Glutamic Acid | HCID 33032 | — |
| 反応物 | Methotrexate | HCID 126941 | — |
| 生成物 | [[(2,4-Diamino-6-Pteridinyl)Methyl]Methyl Amino] Benzoic Acid | HCID 70031183 | — |
反応手順
The title compound was prepared by carboxypeptidase G cleavage of glutamic acid from methotrexate as described in the literature (J. Med. Chem. 24, 1450-1455 (1981)). The yield of I obtained was virtually quantitative.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05952499 |
| 出典データセット | uspto-grants-1999_09 |
| ORD ID | ord-c57135597378462697ba70197b1c3f36 |
| 出典メモ | uspto-grants-1999_09 |