Water → HCID 22000329、化合物

HRID 618503

反応式

HRID 618503 の反応式
[C:1]([O:4][C:5]1[CH:11]=[CH:10][C:8]([NH2:9])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].C(N([CH2:17][CH3:18])CC)C.[C:19]12([C:29]3[CH:38]=[C:37]4[C:32]([CH:33]=[CH:34][C:35]([C:41]5[CH:49]=[CH:48][C:44]([C:45](Cl)=[O:46])=[CH:43][CH:42]=5)=[C:36]4[O:39][CH3:40])=[CH:31][C:30]=3[O:50][CH2:51]COC)[CH2:28][CH:23]3[CH2:24][CH:25]([CH2:27][CH:21]([CH2:22]3)[CH2:20]1)[CH2:26]2.[OH2:55]>C1COCC1>[C:1]([O:4][C:5]1[CH:11]=[CH:10][C:8]([NH:9][C:45](=[O:46])[C:44]2[CH:48]=[CH:49][C:41]([C:35]3[CH:34]=[CH:33][C:32]4[C:37](=[CH:38][C:29]([C:19]56[CH2:26][CH:25]7[CH2:24][CH:23]([CH2:22][CH:21]([CH2:27]7)[CH2:20]5)[CH2:28]6)=[C:30]([O:50][CH3:51])[CH:31]=4)[C:36]=3[O:39][CH2:40][O:55][CH2:17][CH3:18])=[CH:42][CH:43]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 83783Phenol, 4-amino-, 1-acetateHCID 131721374HCID 131721374、化合物

生成物 1

HCID 22000329HCID 22000329、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

970 mg (6.4 mmol) of 4-acetoxyaniline, 50 ml of THF and 990 μl (7 mmol) of triethylamine were introduced into a round-bottomed flask. A solution of 3.2 g (6.4 mmol) of 4-[7-(1-adamantyl)-6-methoxyethoxy-methoxy-2-naphthyl]benzoic acid chloride in THF was added dropwise and the reaction mixture was stirred at room temperature for two hours. The reaction mixture was poured into water and extracted with ethyl acetate and the organic phase was separated by settling, dried over magnesium sulfate and evaporated. The residue obtained was triturated in heptane, filtered and dried. 3.15 g (81%) of the expected compound were collected, which compound had a melting point of 206°-7° C.

後処理

  1. extractionextracted with ethyl acetate
  2. customthe organic phase was separated
  3. dry with materialdried over magnesium sulfate
  4. customevaporated
  5. customThe residue obtained
  6. customwas triturated in heptane
  7. filtrationfiltered
  8. customdried
  9. custom3.15 g (81%) of the expected compound were collected

出典と根拠

ORDレコード
ord-4ab03eda088a46eab3e2f958a65f9208
出典データセット
uspto-grants-1999_09
特許番号
US05952382

関連ノート

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