Hydrochloric Acid → Dihydroartemisinic acid

HRID 618608

反応式

HRID 618608 の反応式
[CH3:1][C@H:2]1[C@@H:7]2[CH2:8][CH2:9][C:10]([CH3:12])=[CH:11][C@@H:6]2[C@H:5]([C:13]([C:15]([OH:17])=[O:16])=[CH2:14])[CH2:4][CH2:3]1.[BH4-].[Na+].Cl>CO>[CH3:1][C@H:2]1[C@@H:7]2[CH2:8][CH2:9][C:10]([CH3:12])=[CH:11][C@@H:6]2[C@H:5]([C@H:13]([C:15]([OH:17])=[O:16])[CH3:14])[CH2:4][CH2:3]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 10922465Artemisinic Acid

生成物 1

HCID 11020893Dihydroartemisinic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A process as claimed in step (x) of claim 1, wherein reduction in step (x) comprises (i) dissolving artemisinic acid and NiCl2.6H2O in dry methanol; (ii) adding sodium borohydride to the resultant solution at 0° C. over a 2 hr. period; (iii) neutralising the solution obtained in step (ii) with 5% aqueous HCl solution and (iv) isolating and crystallizing the dihydro artemisinic acid in ethyl acetate to obtain pure dihydro artemisinic acid.

後処理

  1. customisolating
  2. customcrystallizing the dihydro artemisinic acid in ethyl acetate

出典と根拠

ORDレコード
ord-afead0b5bfee482e863fbb212dd1b31e
出典データセット
uspto-grants-1999_09
特許番号
US05955084

関連ノート

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