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3-(6-Methyl-2-pyridyl)propyn-1-ol → 6-Methyl-2-pyridylpropan-1-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(6-Methyl-2-pyridyl)propyn-1-ol | HCID 21847506 | — |
| 触媒 | Adams' catalyst | HCID 345198 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 6-Methyl-2-pyridylpropan-1-ol | HCID 109132 | 77% |
反応手順
3-(6-methyl -2-pyridyl)propyn-1-ol was dissolved in MeOH (100 mL) and PtO2 (0.09 g) was added. The reaction mixture was hydrogenated at 4 atm for 30 min. The catalyst was filtered off and methanol evaporated in vacuo. The orange oily residue (2 g) was purified by column chromatography (silica gel, ethyl acetate) yielding a yellow oil (77%). MS (DCI) (M+H)+ at m/z 152.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05955440 |
| 出典データセット | uspto-grants-1999_09 |
| ORD ID | ord-e5d6e047d2f744598b83c134f1b1aa1e |
| 出典メモ | uspto-grants-1999_09 |