反应详情

3-(6-methyl -2-pyridyl)propyn-1-ol was dissolved in MeOH (100 mL) and PtO2 (0.09 g) was added. The reaction mixture was hydrogenated at 4 atm for 30 min. The catalyst was filtered off and methanol evaporated in vacuo. The orange oily residue (2 g) was purified by column chromatography (silica gel, ethyl acetate) yielding a yellow oil (77%). MS (DCI) (M+H)+ at m/z 152.

1. filtrationThe catalyst was filtered off
2. custommethanol evaporated in vacuo
3. customThe orange oily residue (2 g) was purified by column chromatography (silica gel, ethyl acetate)