Ethyl phenylacetate → (4-Chlorosulfonyl-phenyl)-acetic acid ethyl ester

HRID 618760ノート

反応式

HRID 618760 の反応式
[Cl:1][S:2]([OH:5])(=O)=[O:3].[C:6]1([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[Cl:1][S:2]([C:9]1[CH:10]=[CH:11][C:6]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:7][CH:8]=1)(=[O:5])=[O:3]

参加物

3

反応物 2

HCID 7590Ethyl phenylacetateHCID 24638Chlorosulfonic acid

生成物 1

HCID 10467900(4-Chlorosulfonyl-phenyl)-acetic acid ethyl ester

反応条件

温度
40 °C

実験手順

Chlorosulfonic acid (87 ml) was added dropwise to ethyl phenylacetate (48 g), and the mixture was stirred at 40° C. for 30 minutes. The reaction mixture was poured into ice water (1000 ml), and the separated oily substance was extracted with methylene chloride. The methylene chloride layer was washed successively with water and a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. Evaporation of the solvent under reduced pressure gave ethyl 4-chlorosulfonylphenylacetate (42 g).

後処理

  1. extractionthe separated oily substance was extracted with methylene chloride
  2. washThe methylene chloride layer was washed successively with water
  3. dry with materiala saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate
  4. customEvaporation of the solvent under reduced pressure

出典と根拠

ORDレコード
ord-a8ab4aa416194c1dbdf66882f42980f9
出典データセット
uspto-grants-1999_09
特許番号
US05955505

反応ノート

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