1-Methyl-4-nitro-3-propyl-1H-pyrazole-5-carboxamide → 4-Amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide

HRID 618804

反応式

HRID 618804 の反応式
[CH3:1][N:2]1[C:6]([C:7]([NH2:9])=[O:8])=[C:5]([N+:10]([O-])=O)[C:4]([CH2:13][CH2:14][CH3:15])=[N:3]1.[H][H]>[Pd].C(OCC)(=O)C>[NH2:10][C:5]1[C:4]([CH2:13][CH2:14][CH3:15])=[N:3][N:2]([CH3:1])[C:6]=1[C:7]([NH2:9])=[O:8]

参加物

5

反応物 2

HCID 27544921-Methyl-4-nitro-3-propyl-1H-pyrazole-5-carboxamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 33380444-Amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A stirred suspension of 1-methyl4-nitro-3-n-propylpyrazole-5-carboxamide (EP-A-0463756; 237.7 g, 1.12 mol) and 5% palladium on charcoal (47.5 g) in ethyl acetate (2.02 l) was hydrogenated at 344.7 kPa (50 psi) and 50° C. for 4 hours, when the uptake of hydrogen was complete. The cool reaction mixture was filtered, then the filter pad washed with ethyl acetate, the combined filtrate and washings thus furnishing an ethyl acetate solution of the title compound (EP-A-0463756) which was of sufficient purity to use directly in the next stage of the reaction sequence (see Preparation 4).

後処理

  1. customThe cool reaction mixture
  2. filtrationwas filtered
  3. washthe filter pad washed with ethyl acetate

出典と根拠

ORDレコード
ord-2c5b9173c24a489b801f00bda7fd8540
出典データセット
uspto-grants-1999_09
特許番号
US05955611

関連ノート

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