Hydrazine hydrate (1:1) → 4-Hydrazinylpyridine-2-carbonitrile

HRID 61887

反応式

HRID 61887 の反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]#[N:9])[CH:3]=1.O.[NH2:11][NH2:12]>O1CCOCC1.O>[C:8]([C:4]1[CH:3]=[C:2]([NH:11][NH2:12])[CH:7]=[CH:6][N:5]=1)#[N:9]

参加物

5

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 6933424-Chloro-2-pyridinecarbonitrile

生成物 1

HCID 629251564-Hydrazinylpyridine-2-carbonitrile

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

4-Chloro-2-cyanopyridine (1 g) was dissolved in hydrazine monohydrate (1 ml) and 1,4-dioxane (10 ml), and stirred overnight under reflux. The reaction solution was diluted with water (30 ml) and extracted repeatedly with ethyl acetate. The organic layer was concentrated to obtain the title compound as a crude product, which was used for the next step without further purification.

後処理

  1. temperatureunder reflux
  2. extractionextracted repeatedly with ethyl acetate
  3. concentrationThe organic layer was concentrated

出典と根拠

ORDレコード
ord-930dc8f5cb434ba09836e381878fb8b4
出典データセット
uspto-grants-2016_09
特許番号
US09440922B2

関連ノート

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