反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:6]=1[F:15])=O.[NH2:16][C:17]([NH2:19])=[S:18]>CO>[BrH:1].[F:15][C:6]1[CH:7]=[CH:8][C:9]([C:11]([F:14])([F:13])[F:12])=[CH:10][C:5]=1[C:3]1[N:16]=[C:17]([NH2:19])[S:18][CH:2]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
A solution of 5.8 g of 2-bromo-1-(2-fluoro-5-trifluoromethyl-phenyl)-ethanone in 44 ml of methanol was treated at room temperature with 2.2 g of thiourea and boiled for 1 hour. 2.8 g of 4-(2-fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals upon cooling to 0° C. and after the addition of 15 ml of diethyl ether.
後処理
- custom2.8 g of 4-(2-fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals
- additionafter the addition of 15 ml of diethyl ether
出典と根拠
- ORDレコード
- ord-f4535cf8a7314c42ba0ce4655d0e8876
- 出典データセット
- uspto-grants-1999_09
- 特許番号
- US05958910
関連ノート
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