Diisopropyl Ether → HCID 10563070、化合物

HRID 619225ノート

反応式

HRID 619225 の反応式
[C:1](OC(=O)C)(=[O:3])C.[NH2:8][C:9]1[S:10][CH:11]=[C:12](/[C:14](=[N:18]/[O:19][C:20](=[O:22])[CH3:21])/[C:15]([OH:17])=[O:16])[N:13]=1.C(OC(C)C)(C)C>C(O)=O>[CH:1]([NH:8][C:9]1[S:10][CH:11]=[C:12](/[C:14](=[N:18]/[O:19][C:20](=[O:22])[CH3:21])/[C:15]([OH:17])=[O:16])[N:13]=1)=[O:3]

参加物

5

反応物 3

HCID 7914Diisopropyl EtherHCID 7918Acetic AnhydrideHCID 11241673(Z)-2-(Acetoxyimino)-2-(2-aminothiazol-4-yl)acetic acid

生成物 1

HCID 10563070HCID 10563070、化合物

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

To acetic anhydride (20.6 ml) was added formic acid (16.6 ml) at 15° C. The mixture was stirred at room temperature for 30 minutes. To the mixture was 2-(2-aminothiazol-4-yl)-2-(Z)-(acetoxyimino)acetic acid (10 g) under ice-cooling, and the reaction mixture was stirred at room temperature for 20 hours. To the mixture was added isopropyl ether (37.2 ml) under ice-cooling, and the mixture was stirred at the same temperature for 1 hour. The resulting precipitate was collected by filtration to give 2-(2-formylaminothiazol-4-yl)-2-(Z)-(acetoxyimino)acetic acid (9.39 g).

後処理

  1. temperaturecooling
  2. stirringthe reaction mixture was stirred at room temperature for 20 hours
  3. temperaturecooling
  4. stirringthe mixture was stirred at the same temperature for 1 hour
  5. filtrationThe resulting precipitate was collected by filtration

出典と根拠

ORDレコード
ord-bdd3d93c29894547a1c5f053388eec09
出典データセット
uspto-grants-1999_09
特許番号
US05958914

反応ノート

読み込み中…