Hydrazine hydrate (1:1) → 2-Naphthohydrazide

HRID 619331

反応式

HRID 619331 の反応式
C([O:3][C:4]([C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=1)=O)C.O.[NH2:17][NH2:18]>C(O)C>[CH:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:14]=[CH:15][C:6]=1[C:4]([NH:17][NH2:18])=[O:3]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 76363Ethyl 2-naphthoate

生成物 1

HCID 1234852-Naphthohydrazide収率 48.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 2-naphthyl carboxylic acid ethyl ester (2.0 g, 9.99 mmol) in absolute ethanol (30 ml) was added hydrazine hydrate (4.85 ml, 99.9 mmol) and the reaction mixture was heated at reflux temperature for 72 h. The reaction mixture was cooled and the precipitate was filtered off, washed with 96% ethanol (2×10 ml) and diethyl ether (3×10 ml), dried in vacuo at 50° C. which afforded 0.9 g (48%) of naphthalene-2-carboxylic acid hydrazide as a solid.

後処理

  1. temperaturethe reaction mixture was heated
  2. temperatureat reflux temperature for 72 h
  3. temperatureThe reaction mixture was cooled
  4. filtrationthe precipitate was filtered off
  5. washwashed with 96% ethanol (2×10 ml) and diethyl ether (3×10 ml)
  6. customdried in vacuo at 50° C. which

出典と根拠

ORDレコード
ord-ba39d8f4d23f4519a20ecf6ea8ca824d
出典データセット
uspto-grants-1999_09
特許番号
US05958957

関連ノート

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