反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][C:6]([CH3:11])=[C:5]2[CH2:12][C:13](OC)=[O:14]>C1COCC1>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][C:6]([CH3:11])=[C:5]2[CH2:12][CH2:13][OH:14]参加物
3
実験手順
To a solution of methyl 5-fluoro-2-methyl-3-indenyl-acetate (24 g) in dry THF (300 ml) lithiumaluminum hydride (6.9 g) is added. The mixture is stirred at room temperature for 1.5 hours. Excess LiAlH4 is destroyed with saturated aqueous NaHSO4 solution. The organic phase is concentrated in vacuo, and the crude product is purified via silica gel column chromatography elution with methylene chloride. The residue is recrystallized from hexane to give 5-fluoro-2-methyl-1H-3-indenyl-(2-hydroxy) ethane (yield 63%; m.p. 65°-66.5° C.).
後処理
- customExcess LiAlH4 is destroyed with saturated aqueous NaHSO4 solution
- concentrationThe organic phase is concentrated in vacuo
- customthe crude product is purified via silica gel column chromatography elution with methylene chloride
- customThe residue is recrystallized from hexane
出典と根拠
- ORDレコード
- ord-5201524978504042abaea87f49dfeefd
- 出典データセット
- uspto-grants-1999_09
- 特許番号
- US05958982
関連ノート
読み込み中…