Nitric Acid → diethyl 5-nitropyridine-2,3-dicarboxylate-N-oxide

HRID 619696ノート

反応式

HRID 619696 の反応式
C(OC(=O)C)(=O)C.[N+:8]1([O-:24])[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:9]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20].[N+:25]([O-])([OH:27])=[O:26]>C(O)(=O)C>[N+:25]([C:12]1[CH:11]=[C:10]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:9]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[N+:8]([O-:24])[CH:13]=1)([O-:27])=[O:26]

参加物

5

反応物 3

HCID 944Nitric AcidHCID 7918Acetic AnhydrideHCID 21847052diethyl pyridine-2,3-dicarboxylate-N-oxide

生成物 1

HCID 15451775diethyl 5-nitropyridine-2,3-dicarboxylate-N-oxide収率 78%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

255 ml of acetic anhydride were added to a mixture of 203.2 g (0.85 mol) of diethyl pyridine-2,3-dicarboxylate-N-oxide in 1.2 1 of glacial acetic acid. 68.3 g (1.06 mol) of 98% strength nitric acid were then added in the course of 40 minutes at from 20 to 28° C. with gentle cooling and stirring and the mixture was stirred at 30° C. for 12 hours. The reaction solution was poured into 3.5 l of ice-water and extracted with methylene chloride. The organic phase was extracted in succession with water, saturated sodium hydrogencarbonate solution and sodium chloride solution, dried over magnesium sulfate and filtered off with suction through silica gel. After concentration, 177.6 g (78% of theory) of diethyl 5-nitropyridine-2,3-dicarboxylate-N-oxide were obtained of nD25 =1.5290. A sample crystallized after relatively long standing; m.p. 84-86° C.

後処理

  1. temperaturewith gentle cooling
  2. stirringthe mixture was stirred at 30° C. for 12 hours
  3. extractionextracted with methylene chloride
  4. extractionThe organic phase was extracted in succession with water, saturated sodium hydrogencarbonate solution and sodium chloride solution
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered off with suction through silica gel
  7. concentrationAfter concentration

出典と根拠

ORDレコード
ord-aaa27bdbb02e41819e848b11b82e2e21
出典データセット
uspto-grants-1999_09
特許番号
US05959116

反応ノート

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