HCID 57073292、化合物 → HCID 57026923、化合物
反応式
C(OC([NH:11][C@H:12]1[C@H:15]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[NH:14][C:13]1=[O:23])=O)C1C=CC=CC=1.[H][H]>[Pd].C(OCC)(=O)C>[NH2:11][C@H:12]1[C@H:15]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[NH:14][C:13]1=[O:23]参加物
5
実験手順
(3S, 4S)-3-benzyloxycarbonylamino-4-phenoxy-azetidin-2-one (63 mg, 0.2 mmole) is hydrogenated with 100 mg of 10% palladium on activated carbon in ethyl acetate (10 ml) at 50 psi hydrogen pressure at room temperature for 2 hours. After removal of catalyst by filtration, deprotected (3S, 4S)-3-amino-4-phenoxy-azetidin-2-one in ethyl acetate is obtained.
後処理
- customAfter removal of catalyst
- filtrationby filtration
出典と根拠
- ORDレコード
- ord-00c52a41839e41a49bde5fac1afecf74
- 出典データセット
- uspto-grants-1999_09
- 特許番号
- US05959123
反応ノート
読み込み中…